Qi Zhong-zheng, Liu Jie, Liu Fa-yu, Sun Chang-fu
Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University. Shenyang 110002;China. E-mail:
Shanghai Kou Qiang Yi Xue. 2013 Dec;22(6):667-70.
To study the effect of pituitary tumour transforming gene (PTTG) on invasion and metastasis of salivary adenoid cystic carcinoma.
The expression of PTTG and bFGF was investigated in 40 salivary adenoid cystic carcinoma tissues and 20 normal salivary tissues by immunohistochemistry. Pearson's Chi-square test and Spearman correlation analysis were used to analyze the data using SPSS 11.5 software package.
The expression of PTTG and bFGF were significantly higher in salivary adenoid cystic carcinoma tissues than in normal salivary gland tissues (P<0.01) and their expression levels were positively correlated (P<0.01).
PTTG and bFGF are highly expressed in salivary adenoid cystic carcinoma. The invasion and metastasis of salivary adenoid cystic carcinoma are correlated with the expression of PTTG. Supported by National Natural Science Foundation of China (81102058).
研究垂体瘤转化基因（PTTG）对涎腺腺样囊性癌侵袭和转移的影响。
采用免疫组织化学法检测40例涎腺腺样囊性癌组织和20例正常涎腺组织中PTTG和bFGF的表达。使用SPSS 11.5软件包进行Pearson卡方检验和Spearman相关性分析。
涎腺腺样囊性癌组织中PTTG和bFGF的表达明显高于正常涎腺组织（P<0.01），且它们的表达水平呈正相关（P<0.01）。
PTTG和bFGF在涎腺腺样囊性癌中高表达。涎腺腺样囊性癌的侵袭和转移与PTTG的表达相关。得到中国国家自然科学基金（81102058）资助。
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