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[微血管减压术治疗面肌痉挛。一年以上随访、临床结果及预后因素。100例系列研究]

[Microsurgical vascular decompression for hemifacial spasm. Follow-up over one year, clinical results and prognostic factors. Study of a series of 100 cases].

作者信息

Marneffe V, Polo G, Fischer C, Sindou M

机构信息

Service de Neurochirurgie, Clinique Saint-Jean, Rue du Marais 104, B-1000 Bruxelles, Belgique.

出版信息

Neurochirurgie. 2003 Nov;49(5):527-35.

Abstract

BACKGROUND AND PURPOSE

The results of a series of 100 patients operated on for hemifacial spasm (HFS), using microsurgical vascular decompression (MVD), are reported.

METHOD

MVD was performed through a retromastoid keyhole approach, under monitoring of brainstem auditory evoked potentials (BAEP) and facial EMG, and consisted in dissection of VII nerve from conflicting vessel(s), and interposition of Teflon fibers and/or screen(s).

RESULTS

The offending vessels found were: the antero-inferior cerebellar artery in 57 cases, the postero-inferior cerebellar artery in 56 cases, the vertebrobasilar artery in 22 cases. A multiple conflict was found in 32 cases (32%). The result was considered excellent if there was no residual spasm, good if only "minimal twitching" remained with relief>80%, poor for spasm relief 20 to 80%, and as a failure if relief<20%. The effect of MVD was satisfying (excellent or good) in 75 patients (75%) at discharge (10th day) and in 85 (85%) after 1 to 18 years follow-up (mean: 5 years). Amongst the latter patients, 29 (34%) experienced a delayed (up to 3(1/2) years in one) cure. Spasm recurrence was noted in 9 cases after satisfying effect on discharge. We encountered following permanent neurological complications: 1 facial palsy, 7 cases of hearing deficit (5 of them complete), and 1 case of IX-X deficit. Neither death nor ischaemic complication at brainstem or cerebellum. Most of our hearing complications occurred before using intraoperative BAEP monitoring (3 cases of cophosis among our first 7 patients vs 2 out of our last 93). Local complications were: 1 meningitis, 8 cases of CSF leakage requiring either a series of lumbar punctures or a lumbar external drain, and 3 cases of wound infection and/or delayed woundhealing requiring surgical treatment.

CONCLUSIONS

Our data are consistent with those of the literature, especially concerning high rate of long-term success and low complication rate of MVD for HFS. We do not recommend early re-operation in case of initial poor result. Again, the necessity of intraoperative BAEP monitoring to prevent hearing morbidity is highlighted.

摘要

背景与目的

报告了100例接受微血管减压术(MVD)治疗面肌痉挛(HFS)患者的系列手术结果。

方法

采用乳突后锁孔入路,在脑干听觉诱发电位(BAEP)和面部肌电图监测下进行MVD,包括从冲突血管中分离出Ⅶ神经,置入聚四氟乙烯纤维和/或屏障。

结果

发现的责任血管有:小脑前下动脉57例,小脑后下动脉56例,椎基底动脉22例。32例(32%)发现存在多重冲突。若无残余痉挛,则结果评为优;若仅残留“轻微抽搐”且缓解率>80%,则评为良;若痉挛缓解率为20%至80%,则评为差;若缓解率<20%,则视为失败。出院时(第10天)75例(75%)患者MVD效果满意(优或良),1至18年随访(平均5年)后85例(85%)患者效果满意。在后者中,29例(34%)经历了延迟治愈(其中1例长达3.5年)。出院时效果满意后9例出现痉挛复发。我们遇到了以下永久性神经并发症:1例面神经麻痹,7例听力减退(其中5例完全性),1例Ⅸ-Ⅹ神经功能缺损。未发生脑干或小脑的死亡或缺血性并发症。我们的大多数听力并发症发生在术中使用BAEP监测之前(前7例中有3例发生耳鸣,而后93例中有2例)。局部并发症有:1例脑膜炎,8例脑脊液漏,需进行一系列腰椎穿刺或腰大池外引流,3例伤口感染和/或伤口延迟愈合需手术治疗。

结论

我们的数据与文献数据一致,特别是关于MVD治疗HFS的长期成功率高和并发症发生率低。对于初始效果不佳的情况,我们不建议早期再次手术。再次强调了术中BAEP监测对预防听力损害的必要性。

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