前列腺素E2、前列环素A1、前列腺素F1-α与烟酰胺腺嘌呤二核苷酸磷酸、β-烟酰胺腺嘌呤二核苷酸对离体兔空肠的生理拮抗作用。
Physiological antagonism between PGE2, PGA1, PGF1-alpha and NADP, beta-NAD on isolated rabbit jejunum.
作者信息
Kovatsis A, Kovatsi-Kotsaki V, Elezoglou B, Kounenis G
出版信息
Arzneimittelforschung. 1976;26(11):1997-9.
The antagonistic action between the prostaglandins PGE2, PGA1 and PGF1-alpha, on the one hand, and nicotinamide-adenine-dinucleotide-phosphate (NADP or TPN) and beta-nicotinamide-adenine-dinucleotide (beta-NAD or DPN) on the other, were experimentally studied on rabbit isolated jejunum. Our results support our previously expressed hypothesis that in the living organism there exist regulatory systems to control the actions of extremely potent substances such as the PGs. NADP and beta-NAD may therefore be grouped together with AMP, ADP and ATP as naturally occurring compounds that antagonise the actions of PGs.
一方面，前列腺素PGE2、PGA1和PGF1-α，与另一方面的烟酰胺腺嘌呤二磷酸（NADP或TPN）和β-烟酰胺腺嘌呤二核苷酸（β-NAD或DPN）之间的拮抗作用，在兔离体空肠上进行了实验研究。我们的结果支持我们之前提出的假设，即在生物体中存在调节系统来控制诸如前列腺素等极有效物质的作用。因此，NADP和β-NAD可以与AMP、ADP和ATP归为一类，作为天然存在的拮抗前列腺素作用的化合物。
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