Ardilouze J-L, Karpe F, Currie J M, Frayn K N, Fielding B A
Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, UK.
Int J Obes Relat Metab Disord. 2004 Feb;28(2):228-33. doi: 10.1038/sj.ijo.0802541.
Blood flow regulation is thought to mediate the metabolic functions of adipose tissue. Different depots, and even different layers within the subcutaneous adipose tissue, may vary in metabolic activity and blood flow. Therefore, we investigated if any differences in subcutaneous adipose tissue blood flow (ATBF) exist at different locations of the anterior abdominal wall.
ATBF was measured 8-10 cm above or below the umbilicus, at 8-10 cm (both sides) from the midline, in 18 healthy subjects (BMI range 18-33 kg/m(2)). Measurements of ATBF were performed using (133)xenon washout, during a stable baseline period and after ingestion of 75 g of glucose.
At baseline, ATBF was greater at the upper level compared to the lower level (4.4+/-0.3 vs 3.8+/-0.2 ml min(-1) 100 g tissue(-1), P=0.005), but was not different between the right and the left sides at either level. ATBF increased in response to oral glucose at all sites. The mean increase at the superior level was also greater than the inferior level (3.5+/-0.7 vs 2.2+/-0.6 ml min(-1) 100 g tissue(-1), P=0.001).
Even at a constant depth and with only 16-20 cm difference between sites, there are significant differences in function of the same adipose depot. These findings have physiological and methodological implications for in vivo metabolic studies of human adipose tissue.
血流调节被认为介导脂肪组织的代谢功能。不同的脂肪储存部位，甚至皮下脂肪组织内的不同层次，其代谢活性和血流可能存在差异。因此，我们研究了前腹壁不同位置的皮下脂肪组织血流（ATBF）是否存在差异。
在18名健康受试者（BMI范围为18 - 33 kg/m²）中，于脐上或脐下8 - 10 cm、距中线8 - 10 cm（两侧）处测量ATBF。在稳定的基线期和摄入75 g葡萄糖后，使用（133）氙洗脱法进行ATBF测量。
在基线时，上层的ATBF高于下层（4.4±0.3 vs 3.8±0.2 ml min⁻¹ 100 g组织⁻¹，P =
