纤连蛋白：生理学与疾病视角
Fibulins: physiological and disease perspectives.
作者信息
Argraves W Scott, Greene Lisa M, Cooley Marion A, Gallagher William M
机构信息
Medical University of South Carolina, Department of Cell Biology, 173 Ashley Avenue, Charleston, South Carolina 29425, USA.
出版信息
EMBO Rep. 2003 Dec;4(12):1127-31. doi: 10.1038/sj.embor.7400033.
Abstract
The fibulins are a family of proteins that are associated with basement membranes and elastic extracellular matrix fibres. This review summarizes findings from studies of animal models of fibulin deficiency, human fibulin gene mutations, human tumours and injury models that have advanced our understanding of the normal and pathological roles of members of this formerly obscure family.
摘要
纤连蛋白是一类与基底膜和弹性细胞外基质纤维相关的蛋白质。本综述总结了对纤连蛋白缺乏动物模型、人类纤连蛋白基因突变、人类肿瘤及损伤模型的研究结果，这些研究增进了我们对这个曾鲜为人知的蛋白家族成员的正常及病理作用的理解。
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