COP9信号体：一种用于Cullin泛素连接酶的组装和维持平台？
The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?
作者信息
Wolf Dieter A, Zhou Chunshui, Wee Susan
机构信息
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
出版信息
Nat Cell Biol. 2003 Dec;5(12):1029-33. doi: 10.1038/ncb1203-1029.
The COP9 signalosome (CSN) is a highly conserved protein complex implicated in diverse biological functions that involve ubiquitin-mediated proteolysis. Paradoxically, conserved enzymatic activities associated with CSN inhibit cullin ubiquitin ligase activity in vitro, whereas mutational analysis suggests that CSN promotes cullin-dependent proteolysis in vivo. This apparent paradox can be resolved in a model that proposes CSN-mediated cullin inhibition is a prerequisite for the proper assembly and maintenance of active cullin ubiquitin ligase complexes.
COP9信号体（CSN）是一种高度保守的蛋白质复合物，参与多种涉及泛素介导的蛋白水解的生物学功能。矛盾的是，与CSN相关的保守酶活性在体外抑制cullin泛素连接酶活性，而突变分析表明CSN在体内促进依赖cullin的蛋白水解。在一个模型中可以解决这一明显的矛盾，该模型提出CSN介导的cullin抑制是活性cullin泛素连接酶复合物正确组装和维持的先决条件。
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