Department of Psychiatry, Jining Medical University, Jianshe South Road No. 45, Jining, Shandong, China.
Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Jining Medical University, Jining, Shandong, China.
Mol Med. 2023 Jun 26;29(1):80. doi: 10.1186/s10020-023-00675-w.
c-Jun activation domain binding protein-1 (JAB1) is a multifunctional regulator that plays vital roles in diverse cellular processes. It regulates AP-1 transcriptional activity and also acts as the fifth component of the COP9 signalosome complex. While JAB1 is considered an oncoprotein that triggers tumor development, recent studies have shown that it also functions in neurological development and disorders. In this review, we summarize the general features of the JAB1 gene and protein, and present recent updates on the regulation of JAB1 expression. Moreover, we also highlight the functional roles and regulatory mechanisms of JAB1 in neurodevelopmental processes such as neuronal differentiation, synaptic morphogenesis, myelination, and hair cell development and in the pathogenesis of some neurological disorders such as Alzheimer's disease, multiple sclerosis, neuropathic pain, and peripheral nerve injury. Furthermore, current challenges and prospects are discussed, including updates on drug development targeting JAB1.
c-Jun 激活域结合蛋白-1（JAB1）是一种多功能调节剂，在多种细胞过程中发挥着重要作用。它调节 AP-1 转录活性，并且作为 COP9 信号体复合物的第五个组成部分。虽然 JAB1 被认为是触发肿瘤发展的癌蛋白，但最近的研究表明它也在神经发育和疾病中发挥作用。在这篇综述中，我们总结了 JAB1 基因和蛋白的一般特征，并介绍了 JAB1 表达调控的最新进展。此外，我们还强调了 JAB1 在神经发育过程中的功能作用和调节机制，如神经元分化、突触形态发生、髓鞘形成、毛细胞发育，以及在一些神经疾病的发病机制中的作用，如阿尔茨海默病、多发性硬化症、神经性疼痛和周围神经损伤。此外，还讨论了当前的挑战和前景，包括针对 JAB1 的药物开发的最新进展。
