Meier Pascal, Silke John
The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK.
Nat Cell Biol. 2003 Dec;5(12):1035-8. doi: 10.1038/ncb1203-1035.
This year's Cold Spring Harbor meeting on programmed cell death (September 17-21, 2003), organised by Craig Thompson and Junying Yuan, was proof that the 'golden age' of research in this field is far from over. There was a flurry of fascinating insights into the regulation of diverse apoptotic pathways and unexpected non-apoptotic roles for some of the key apoptotic regulators and effectors. In addition to their role in cell death, components of the apoptotic molecular machinery are now known to also function in a variety of essential cellular processes, such as regulating glucose homeostasis, lipid metabolism, cell proliferation and differentiation.
今年由克雷格·汤普森（Craig Thompson）和袁钧瑛（Junying Yuan）组织的冷泉港程序性细胞死亡会议（2003年9月17日至21日）证明，该领域研究的“黄金时代”远未结束。会议上涌现出了一系列关于多种凋亡途径调控的迷人见解，以及一些关键凋亡调节因子和效应蛋白意想不到的非凋亡作用。除了在细胞死亡中的作用外，现在已知凋亡分子机制的组成部分在多种重要的细胞过程中也发挥作用，例如调节葡萄糖稳态、脂质代谢、细胞增殖和分化。
