氟代脱氧葡萄糖正电子发射断层显像/计算机断层扫描在淋巴瘤患者再分期中的应用
FDG-PET/CT in re-staging of patients with lymphoma.
作者信息
Freudenberg L S, Antoch G, Schütt P, Beyer T, Jentzen W, Müller S P, Görges R, Nowrousian M R, Bockisch A, Debatin J F
机构信息
Clinic and Policlinic for Nuclear Medicine, University of Essen, Essen, Germany.
出版信息
Eur J Nucl Med Mol Imaging. 2004 Mar;31(3):325-9. doi: 10.1007/s00259-003-1375-y. Epub 2003 Nov 26.
The aim of this study was to evaluate the clinical significance of combined fluorine-18 fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) in patients with lymphoma, and to compare the FDG-PET/CT staging results with those of FDG-PET and CT alone. Twenty-seven patients were studied. Each patient had clinical follow-up for >12 months and entered complete follow-up evaluation. Patient-based evaluation showed a sensitivity of 78% for CT alone, 86% for FDG-PET alone, 93% for CT and FDG-PET read side by side, and 93% for combined FDG-PET/CT imaging. Region-based evaluation showed a sensitivity for regional lymph node involvement of 61%, 78%, 91% and 96% respectively. FDG-PET/CT imaging is superior to CT alone ( P=0.02) and has additional benefit over FDG-PET alone due to exact anatomical localisation. We conclude that FDG-PET/CT imaging is accurate in re-staging lymphoma and offers advantages over separate FDG-PET and CT imaging.
本研究的目的是评估氟-18氟脱氧葡萄糖正电子发射断层扫描与计算机断层扫描（FDG-PET/CT）联合应用于淋巴瘤患者的临床意义，并将FDG-PET/CT分期结果与单独的FDG-PET和CT分期结果进行比较。对27例患者进行了研究。每位患者均接受了超过12个月的临床随访，并进行了完整的随访评估。基于患者的评估显示，单独CT的敏感性为78%，单独FDG-PET的敏感性为86%，CT和FDG-PET并排阅片的敏感性为93%，联合FDG-PET/CT成像的敏感性为93%。基于区域的评估显示，区域淋巴结受累的敏感性分别为61%、78%、91%和96%。FDG-PET/CT成像优于单独的CT（P=0.02），并且由于精确的解剖定位，相对于单独的FDG-PET具有额外的优势。我们得出结论，FDG-PET/CT成像在淋巴瘤再分期方面是准确的，并且相对于单独的FDG-PET和CT成像具有优势。
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