全反式维甲酸诱导急性早幼粒细胞白血病患者发生结节性红斑。
All- trans-retinoic acid-induced erythema nodosum in patients with acute promyelocytic leukemia.
作者信息
Kuo M C, Dunn P, Wu J H, Shih L Y
机构信息
Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, 199 Tung-Hwa North Road, 105, Taipei, Taiwan.
出版信息
Ann Hematol. 2004 Jun;83(6):376-80. doi: 10.1007/s00277-003-0790-2. Epub 2003 Nov 26.
Erythema nodosum associated with all- trans-retinoic acid (ATRA) for acute promyelocytic leukemia (APL) is very rare. We describe four patients with classic APL who developed erythema nodosum during ATRA therapy. Fever and subsequent multiple painful erythematous nodules over extremities developed on D11, D16, D17, and D19, respectively, after ATRA therapy. The skin biopsy taken from each patient was consistent with erythema nodosum. All patients received short course of steroids. Fever subsided rapidly and the skin lesions regressed completely. All patients achieved complete remission without withdrawal of ATRA. ATRA seemed to be the most possible etiology of erythema nodosum in our patients. Short-term use of steroid is very effective in ATRA-induced erythema nodosum.
全反式维甲酸（ATRA）治疗急性早幼粒细胞白血病（APL）相关的结节性红斑非常罕见。我们描述了4例典型APL患者，他们在ATRA治疗期间出现了结节性红斑。分别在ATRA治疗后的第11天、第16天、第17天和第19天，出现发热，随后四肢出现多个疼痛性红斑结节。取自每位患者的皮肤活检结果均符合结节性红斑。所有患者均接受了短期类固醇治疗。发热迅速消退，皮肤病变完全消退。所有患者在未停用ATRA的情况下均实现了完全缓解。ATRA似乎是我们患者结节性红斑最可能的病因。短期使用类固醇对ATRA诱导的结节性红斑非常有效。
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