来自生长于土耳其的茴芹属植物的抗菌化合物。

Antimicrobial compounds from Pimpinella species growing in Turkey.

作者信息

Tabanca Nurhayat, Bedir Erdal, Kirimer Nese, Baser K Husnu Can, Khan Shabana I, Jacob Melissa R, Khan Ikhlas A

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.

出版信息

Planta Med. 2003 Oct;69(10):933-8. doi: 10.1055/s-2003-45103.

DOI:10.1055/s-2003-45103

PMID:14648397

Abstract

A new, 4-(2-propenyl)-phenyl angelate ( 1) and four known phenylpropanoids ( 2 - 5), were isolated from Pimpinella isaurica, a species endemic in Turkey. One new sesquiterpene, 1-methyl-4-(5-methyl-1-methylenehex-4-enyl)-7-oxabicyclo[4.1.0]heptane ( 6) was obtained from P. aurea and two known phenylpropanoids were isolated ( 7, 8), from P. corymbosa. The structure elucidation of the new compounds 1 and 6 was achieved by a combination of one- ( (1)H, and (13)C) and two-dimensional NMR techniques (G-DQF-COSY, G-HMQC, and G-HMBC) and LC-ESI-FTMS. Compounds 1, 2, 4, 6, 7, 8 have been evaluated for their antimalarial and antimicrobial activities. Compound 1, 2, 4, 6, 8 had antimicrobial activity against Mycobacterium intracellulare with IC (50) values of 7.0, 15.0, 2.5, 10.0 and 1.5 microg/mL, respectively.

摘要

从土耳其特有的物种小亚细亚茴芹（Pimpinella isaurica）中分离出一种新的4-(2-丙烯基)-苯基当归酸酯（1）和四种已知的苯丙素类化合物（2 - 5）。从金色茴芹（P. aurea）中获得了一种新的倍半萜，1-甲基-4-(5-甲基-1-亚甲基己-4-烯基)-7-氧杂双环[4.1.0]庚烷（6），并从伞形茴芹（P. corymbosa）中分离出两种已知的苯丙素类化合物（7, 8）。通过一维（(1)H和(13)C）和二维核磁共振技术（G-DQF-COSY、G-HMQC和G-HMBC）以及液相色谱-电喷雾-傅里叶变换质谱联用对新化合物1和6进行了结构解析。对化合物1、2、4、6、7、8的抗疟疾和抗菌活性进行了评估。化合物1、2、4、6、8对胞内分枝杆菌具有抗菌活性，其半数抑制浓度（IC(50)）值分别为7.0、15.0、2.5、10.0和1.5微克/毫升。