来自灰毛泽兰的两种新苯并呋喃及其抗菌活性。

Two new benzofuranes from Eupatorium aschenbornianum and their antimicrobial activity.

作者信息

Rios María Yolanda, Aguilar-Guadarrama A Berenice, Navarro Victor

机构信息

Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México.

出版信息

Planta Med. 2003 Oct;69(10):967-70. doi: 10.1055/s-2003-45113.

DOI:10.1055/s-2003-45113

PMID:14648407

Abstract

Through a bioassay-guided fractionation, from the aerial parts of the medicinal plant Eupatorium aschenbornianum were isolated two new benzofurane compounds, 5-acetyl-3beta-angeloyloxy-2beta-(1-hydroxyisopropyl)-2,3-dihydrobenzofurane ( 1) and 5-acetyl-3beta-angeloyloxy-2beta-(1-hydroxyisopropyl)-6-methoxy-2,3-dihydrobenzofurane ( 2) in addition to 4-hydroxy-3,5-diprenylacetophenone, espeletone ( 3), encecalinol ( 4), beta-sitosterol and stigmasterol. The antimicrobial evaluation of these natural products showed that 1 [MIC = 200 microg/mL against T. mentagrophytes and 100 microg/mL against T. rubrum], 2 [MIC = 50 microg/mL towards both] and 3 [MIC = 100 microg/mL against both] were active against dermatophytes, while 4 was active against all of microorganisms assayed [MIC = 12.5 microg/mL ( T. mentagrophytes), 12.5 microg/mL ( T. rubrum), 100 microg/mL ( C. albicans) and 200 microg/mL ( A. niger)].

摘要

通过生物活性导向分离法，从药用植物阿森博氏泽兰的地上部分分离出两种新的苯并呋喃化合物，5-乙酰基-3β-当归酰氧基-2β-(1-羟基异丙基)-2,3-二氢苯并呋喃(1)和5-乙酰基-3β-当归酰氧基-2β-(1-羟基异丙基)-6-甲氧基-2,3-二氢苯并呋喃(2)，此外还分离出4-羟基-3,5-二异戊烯基苯乙酮、埃斯佩莱酮(3)、恩塞卡诺醇(4)、β-谷甾醇和豆甾醇。对这些天然产物的抗菌活性评估表明，1[对须癣毛癣菌的最低抑菌浓度(MIC)=200μg/mL，对红色毛癣菌的MIC=100μg/mL]、2[对两者的MIC=50μg/mL]和3[对两者的MIC=100μg/mL]对皮肤癣菌有活性，而4对所有测试微生物都有活性[对须癣毛癣菌的MIC=12.5μg/mL，对红色毛癣菌的MIC=12.5μg/mL，对白色念珠菌的MIC=100μg/mL，对黑曲霉的MIC=200μg/mL]。