Vonshak A, Barazani O, Sathiyamoorthy P, Shalev R, Vardy D, Golan-Goldhirsh A
Ben-Gurion University of the Negev, Jacob Blaustein Institute for Desert Research, Albert Katz Department of Dryland Biotechnologies, Desert Plant Biotechnology Laboratory, Sede Boqer Campus, 84990, Israel.
Phytother Res. 2003 Nov;17(9):1123-5. doi: 10.1002/ptr.1399.
In this study, twenty-eight South Indian medicinal plants were screened for their anti-fungal activity against six species of fungi (Trichophyton mentagrophytes, T. rubrum, T. soudanense, Candida albicans, Torulopsis glabrata, and C. krusei). Three plant species extracts, Celastrus paniculatus, Eriodendron anfractuosum and Ficus glomerata showed inhibitory activity. An aqueous extract of galls of Terminalia chebula showed inhibitory effects on three dermatophytes (Trichophyton spp.) and three yeasts (Candida spp.). Seeds extract of T. chebula inhibited only the growth of T. glabrata. An aqueous extract of T. chebula showed inhibitory effects higher than those measured in ethanol extracts. It is therefore suggested that tannins are plausible candidates for the anti-dermatophytic effects of T. chebula. Chebulinic acid, a known tannin of T. chebula was tested and found not inhibitory, thus a search for the active compound is needed.
在本研究中，对28种南印度药用植物针对6种真菌（须癣毛癣菌、红色毛癣菌、苏丹毛癣菌、白色念珠菌、光滑球拟酵母和克柔念珠菌）的抗真菌活性进行了筛选。三种植物提取物，即南蛇藤、缠绕银叶树和聚果榕显示出抑制活性。诃子瘿的水提取物对三种皮肤癣菌（毛癣菌属）和三种酵母（念珠菌属）显示出抑制作用。诃子种子提取物仅抑制光滑球拟酵母的生长。诃子的水提取物显示出比乙醇提取物更高的抑制作用。因此，单宁被认为是诃子抗皮肤癣菌作用的可能候选物。对诃子中已知的单宁诃子酸进行了测试，发现其没有抑制作用，因此需要寻找活性化合物。
