Boey M L, Wee G B, Mohan C, Howe H S, Chan S H, Feng P H
Department of Medicine IV, Tan Tock Seng Hospital, Singapore.
J Rheumatol. 1992 Oct;19(10):1517-9.
The HLA-A, B, C, DR and DQ antigens were determined in 50 Singapore Chinese patients with rheumatoid arthritis (RA). There was a significant increase in the prevalence of HLA-Bw46, DRw53 and DQ3 in patients with RA. The linkage disequilibrium between Bw46 and DRw53 explains this association. This major histocompatibility complex association differs from the HLA-DR4 link in Caucasian populations and suggests that RA is an immunogenetically heterogeneous disease.
对50名新加坡华裔类风湿关节炎（RA）患者进行了HLA - A、B、C、DR和DQ抗原检测。类风湿关节炎患者中HLA - Bw46、DRw53和DQ3的患病率显著增加。Bw46和DRw53之间的连锁不平衡解释了这种关联。这种主要组织相容性复合体关联不同于白种人群中的HLA - DR4关联，提示类风湿关节炎是一种免疫遗传学异质性疾病。
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