Sowter Heidi Michelle, Ferguson Mary, Pym Caroline, Watson Peter, Fox Stephen B, Han Cheng, Harris Adrian L
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK.
J Pathol. 2003 Dec;201(4):573-80. doi: 10.1002/path.1486.
Ductal carcinoma in situ (DCIS) of the breast is an early, non-invasive lesion and the prognosis is associated with the extent of necrosis and cell death within the tumour. Two cell death genes, BNip3 and NIX, are up-regulated in response to hypoxia in breast carcinoma cells, although any involvement of either gene in disease progression is currently unknown. This study has analysed the expression of BNip3 and NIX in 56 samples of breast DCIS, as well as in adjacent benign and invasive breast tissue. Both genes are strongly expressed in the epithelial component of a subset of DCIS and invasive disease. The data show a correlation between high expression of BNip3 in the DCIS cells and a high-grade, necrotic lesion that is likely to be associated with invasive tumour. BNip3 was present in tumour-associated macrophages and in apocrine metaplastic lesions. Expression of NIX did not correlate with any of the parameters investigated.
乳腺导管原位癌（DCIS）是一种早期非侵袭性病变，其预后与肿瘤内坏死和细胞死亡的程度相关。两个细胞死亡基因，即BNip3和NIX，在乳腺癌细胞缺氧时会上调，尽管目前尚不清楚这两个基因中的任何一个是否参与疾病进展。本研究分析了56例乳腺DCIS样本以及相邻的良性和侵袭性乳腺组织中BNip3和NIX的表达。这两个基因在DCIS和侵袭性疾病子集的上皮成分中均强烈表达。数据显示，DCIS细胞中BNip3的高表达与高级别坏死性病变相关，而该病变可能与侵袭性肿瘤有关。BNip3存在于肿瘤相关巨噬细胞和大汗腺化生病变中。NIX的表达与所研究的任何参数均无相关性。
