Stebbing Justin, Gazzard Brian, Newsom-Davis Tom, Nelson Mark, Patterson Steve, Gotch Frances, Mandalia Sundhiya, Bower Mark
Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom.
Int J Cancer. 2004 Jan 20;108(3):473-4. doi: 10.1002/ijc.11601.
Infection with HIV-1 is known to impair B cell function. To further elucidate the role of B cells during infection and tumorigenesis, we studied their numbers in cases of AIDS-related Kaposi's sarcoma (KS) during the HAART era. Patients with AIDS-related KS were identified from a database of 4,480 HIV-1 positive individuals and the incidence of KS and rate ratio was stratified according to nadir number of B cells, measured as the CD19 count. In an unadjusted model, we observed that lower B cell counts were associated with a statistically significant increased risk of KS development (p < 0.001). We also observed a trend toward increased counts during KS resolution. When adjusted for nadir CD4 count in a multi-variable model, higher B cell counts were protective against KS development (p = 0.015). These data highlight a potential role for B cells and therefore the humoral immune system in KS aetiopathogenesis.
已知感染HIV-1会损害B细胞功能。为了进一步阐明B细胞在感染和肿瘤发生过程中的作用，我们研究了高效抗逆转录病毒治疗（HAART）时代艾滋病相关卡波西肉瘤（KS）病例中B细胞的数量。从一个包含4480名HIV-1阳性个体的数据库中识别出艾滋病相关KS患者，并根据以CD19计数衡量的B细胞最低点数量对KS的发病率和率比进行分层。在一个未调整的模型中，我们观察到较低的B细胞计数与KS发生风险在统计学上显著增加相关（p < 0.001）。我们还观察到在KS消退期间计数有增加的趋势。在多变量模型中对最低点CD4计数进行调整后，较高的B细胞计数对KS发生有保护作用（p = 0.015）。这些数据突出了B细胞以及因此体液免疫系统在KS发病机制中的潜在作用。
