González J Benito, González F Benito, Muñoz Herrera A, Nieto García A, Antúñez Plaza P, Pérez Plasencia D, del Cañizo Alvarez A
Servicio de ORL y Patología cérvico-facial, Hospital Universitario de Salamanca.
An Otorrinolaringol Ibero Am. 2003;30(5):501-11.
Plasmocytomas are neoplasic disorders arising from plasma cells that include Multiple Myeloma (MM) Solitary Plasmocytoma of the bone and Extramedullary Plasmacytoma (EMP). EMP are solitary tumours consisting of plasma cell proliferation that occurs in locations other than bone. A variable percentage may be associated at a later date with the development of MM. EMP represent up to 4% of nonepithelial tumours of the upper respiratory tract. They generally occur in the submucosal tissue of the upper airways (80% of cases), with a predilection for nasopharynx, nasal cavity, paranasal sinuses and tonsils. We report 3 cases of Extramedullary Plasmocytoma located one in the upper respiratory tract. All the patients underwent surgical resection or biopsy of the lesion that allowed the histological study, which showed a plasma cell proliferation. Serum and bone marrow studies conclude the diagnosis of Extramedullary Plasmocytoma. The treatment was radiotherapy, with or without previously surgery. Three patients are currently under close follow-up and no evidence of recurrence has been found. We review the clinic, diagnostic, therapeutic and prognostic aspects of this kind of tumours.
浆细胞瘤是起源于浆细胞的肿瘤性疾病，包括多发性骨髓瘤（MM）、骨孤立性浆细胞瘤和髓外浆细胞瘤（EMP）。EMP是由浆细胞增殖形成的孤立性肿瘤，发生于骨骼以外的部位。可变比例的EMP在后期可能会发展为MM。EMP占上呼吸道非上皮性肿瘤的4%。它们通常发生在上气道的黏膜下组织（80%的病例），好发于鼻咽、鼻腔、鼻窦和扁桃体。我们报告3例髓外浆细胞瘤，其中1例位于上呼吸道。所有患者均接受了病变的手术切除或活检，以便进行组织学研究，结果显示为浆细胞增殖。血清和骨髓检查确诊为髓外浆细胞瘤。治疗方法为放疗，可联合或不联合术前手术。3例患者目前正在密切随访中，未发现复发迹象。我们回顾了这类肿瘤的临床、诊断、治疗和预后方面的情况。
