β-肾上腺素能兴奋剂对人体皮肤组胺反应的抑制作用。I. 非诺特罗的研究。
Inhibitory effect of beta-adrenergic stimulants on the histamine reaction in human skin. I. Studies with fenoterol.
作者信息
Jorde W, Schata M
出版信息
Arzneimittelforschung. 1976;26(11):2103-5.
PMID:14649
Abstract
In 20 volunteers histamine inhibition by fenoterol (Th 1165 a) was studied. The wheal and erythema reaction caused by intracutaneous application of 5 mug histamine can be inhibited by applying fenoterol in doses from 100--400 mug in form of a metered aerosol on the skin 5 min before the injection of histamine. In this study the dose-reaction effect yielded on ED50 of 140 mug fenoterol.
摘要
对20名志愿者研究了非诺特罗（Th 1165 a）对组胺的抑制作用。在皮内注射5微克组胺前5分钟，以定量气雾剂形式在皮肤上涂抹100 - 400微克剂量的非诺特罗，可抑制由皮内注射组胺引起的风团和红斑反应。在本研究中，非诺特罗的半数有效剂量（ED50）的剂量反应效应为140微克。
Zotero 插件