Inhibitory effect of beta-adrenergic stimulants on the histamine reaction of the human skin. II. Studies with several derivatives in regard to the dosage used and reaction depending on time.

In 56 volunteers the inhibitory effects of the beta-adrenergic stimulants fenoterol, salbutamol, isoproterenol, orciprenaline, terbutaline, epinephrine and phenylephrine were studied. There was a difference between the substances in regard to the applied dose and duration of inhibitory effect. The latter parameter particularly depended on the hydrosolubility of the individual substances. Fenoterol and salbutamol had a very low solubility and a very strong and long-lasting effect. The possibly stronger adhesive power of these drugs in the tissue according to their poor solubility and the site of action in the reactive systems of the skin are discussed giving preference to the vascular system over the mast-cells and cAMP.