Fügner A
Int Arch Allergy Appl Immunol. 1977;54(1):78-87. doi: 10.1159/000231810.
IgE-mediated histamine release was studied using the method of passive peritoneal anaphylaxis (PPA) in the rat. Some beta-adrenergic stimulants markedly inhibited this reaction in vivo, the order of potency (ED50 microng/kg i.v.) of agents tested being fenoterol (6), salbutamol (40) and isoproterenol (94). Higher activity against the simultaneously measured dye extravasation suggested a dual effect of the drugs on both the cellular (inhibition of histamine release) and the vascular level. The order of potency in modifying vascular injury was, however, reversed, isoproterenol and not fenoterol being relatively more active here, as could be shown by further experiments. Inhibition of histamine release is discussed with respect to (a) methodical requirements and (b) the suggestion that beta2-receptor stimulants (fenoterol, salbutamol) are more selective than isoproterenol.
采用大鼠被动腹膜过敏反应（PPA）方法研究了IgE介导的组胺释放。一些β-肾上腺素能兴奋剂在体内显著抑制了这种反应，所测试药物的效价顺序（静脉注射ED50微克/千克）为非诺特罗（6）、沙丁胺醇（40）和异丙肾上腺素（94）。对同时测量的染料外渗具有更高的活性，提示这些药物对细胞水平（抑制组胺释放）和血管水平都有双重作用。然而，在改变血管损伤方面的效价顺序相反，进一步实验表明，异丙肾上腺素而非非诺特罗在此处相对更具活性。关于组胺释放的抑制，将从（a）方法学要求和（b）β2受体兴奋剂（非诺特罗、沙丁胺醇）比异丙肾上腺素更具选择性这一观点进行讨论。
