Laskowski Roman A, Watson James D, Thornton Janet M
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
J Struct Funct Genomics. 2003;4(2-3):167-77. doi: 10.1023/a:1026127927612.
Here we describe various methods currently under development aimed at identifying a protein's function from its three-dimensional structure. We are combining a number of these methods to create a pipeline of applications, called ProFunc, which will take a given 3D structure, run all the applications on it and compile and summarise the results obtained. The aim is to provide a best guess as to the protein's function from the evidence provided by the different methods. Here we present three examples, using structures solved by the Midwest Center for Structural Genomics consortium, illustrating the strengths and weaknesses of current approaches.
在此，我们描述了目前正在开发的各种方法，旨在从蛋白质的三维结构确定其功能。我们正在将其中一些方法结合起来，创建一个应用程序管道，称为ProFunc，它将获取给定的三维结构，在其上运行所有应用程序，并编译和总结所得结果。目的是根据不同方法提供的证据，对蛋白质的功能做出最佳猜测。在此，我们给出三个例子，使用由中西部结构基因组学联盟解析的结构，说明当前方法的优缺点。
