Falquet Laurent, Pagni Marco, Bucher Philipp, Hulo Nicolas, Sigrist Christian J A, Hofmann Kay, Bairoch Amos
Swiss Institute of Bioinformatics, Swiss Institute for Experimental Cancer Research (ISREC), CH-1066 Epalinges /Lausanne, Switzerland.
Nucleic Acids Res. 2002 Jan 1;30(1):235-8. doi: 10.1093/nar/30.1.235.
PROSITE [Bairoch and Bucher (1994) Nucleic Acids Res., 22, 3583-3589; Hofmann et al. (1999) Nucleic Acids Res., 27, 215-219] is a method of identifying the functions of uncharacterized proteins translated from genomic or cDNA sequences. The PROSITE database (http://www.expasy.org/prosite/) consists of biologically significant patterns and profiles designed in such a way that with appropriate computational tools it can rapidly and reliably help to determine to which known family of proteins (if any) a new sequence belongs, or which known domain(s) it contains.
PROSITE [拜罗什和布赫尔(1994年),《核酸研究》,22卷,3583 - 3589页;霍夫曼等人(1999年),《核酸研究》,27卷,215 - 219页]是一种识别从基因组或cDNA序列翻译而来的未表征蛋白质功能的方法。PROSITE数据库(http://www.expasy.org/prosite/)由具有生物学意义的模式和图谱组成,其设计方式使得借助适当的计算工具,它能够快速且可靠地帮助确定新序列属于哪个已知蛋白质家族(如果有的话),或者它包含哪些已知结构域。