[Effect of GABA on phosphoinositide cycle and membrane lipid modification in the brain synaptosomes of rats in hypokinesia].
作者信息
Akopian V P, Melkonian K V, Tadevosian Iu V, Batikian T B
机构信息
Department of Pharmacology, Yerevan State Medical University, ul. Koryuna 2, Erevan, 375025 Armenia.
出版信息
Eksp Klin Farmakol. 2003 Sep-Oct;66(5):6-9.
PMID:14650205
Abstract
The influence of a 30-day hypokinesia on the phosphoinositide cycle (PIC) initiation and on the inclusion of [14C]-arachidonic acid into cerebral synaptosome phospholipids was studied in rats. The results show that the catabolism of phospholipids prevails on the background of signal transduction in synaptosomes on the 30th day of hypokinesia. The effect of gamma-aminobutyric acid (GABA) is manifested by a sharp increase in the PIC activity 5 sec upon initiation and leads to normalization of the PIC activity in the late stage (5 min).
摘要
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