[Effects of pharmacological substances structurally close to gamma-aminobutyric acid on the synthesis, metabolism and membrane transport systems in the cerebral cortex of rats in vitro].

Effects of pantogam (calcium homopantotenate), piracetam, phenibut (beta-phenyl-GABA), sodium hydroxybutyrate and sodium valproate (depakine) at concentrations of 100 and 500 microM on the activities of glutamic acid decarboxylase, GABA-transaminase, Na, K- and Mg-ATPases, synaptosomal uptake and K+-stimulated release of 3H-GABA were studied in vitro. None of the compounds influenced the 3H-GABA uptake and activity of Mg-ATPase. Piracetam and phenibut stimulated slightly Na, K-ATPase. Phenibut and hydroxybutyrate exerted the inhibitory effect on GABA-transaminase activity. Hydroxybutyrate produced a moderate decrease of 3H-GABA release and suppressed the activity of glutamic acid decarboxylase.