Kovalev G I, Prikhozhan A V, Eremenko A V
Farmakol Toksikol. 1986 Jul-Aug;49(4):19-22.
Effects of pantogam (calcium homopantotenate), piracetam, phenibut (beta-phenyl-GABA), sodium hydroxybutyrate and sodium valproate (depakine) at concentrations of 100 and 500 microM on the activities of glutamic acid decarboxylase, GABA-transaminase, Na, K- and Mg-ATPases, synaptosomal uptake and K+-stimulated release of 3H-GABA were studied in vitro. None of the compounds influenced the 3H-GABA uptake and activity of Mg-ATPase. Piracetam and phenibut stimulated slightly Na, K-ATPase. Phenibut and hydroxybutyrate exerted the inhibitory effect on GABA-transaminase activity. Hydroxybutyrate produced a moderate decrease of 3H-GABA release and suppressed the activity of glutamic acid decarboxylase.
研究了泛多利（高泛酸钙）、吡拉西坦、苯乙胺（β-苯基-GABA）、羟基丁酸钠和丙戊酸钠（德巴金）在浓度为100和500微摩尔时对谷氨酸脱羧酶、GABA转氨酶、钠钾-ATP酶和镁-ATP酶活性、突触体摄取以及3H-GABA钾刺激释放的体外影响。这些化合物均未影响3H-GABA摄取和镁-ATP酶活性。吡拉西坦和苯乙胺对钠钾-ATP酶有轻微刺激作用。苯乙胺和羟基丁酸钠对GABA转氨酶活性有抑制作用。羟基丁酸钠使3H-GABA释放适度减少，并抑制谷氨酸脱羧酶活性。
