Darj E, Crona N, Nilsson S
Department of Obstetrics and Gynaecology, Falun Hospital, Sweden.
Maturitas. 1992 Dec;15(3):209-15. doi: 10.1016/0378-5122(92)90204-h.
Thirty women with climacteric symptoms were treated for 4 months with 2 mg 17 beta-oestradiol and different doses of progesterone (50, 100 or 200 mg). The concentrations of total and free cholesterol, phospholipids, triglycerides (TG), apoprotein A1 and apoprotein B were determined in high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) fractions and in serum. HDL levels increased and LDL levels decreased, while TG levels in VLDL remained unchanged, which indicates that the lipoprotein pattern is oestrogen-induced and that progesterone exerts little or no influence.
30名有更年期症状的女性接受了为期4个月的治疗，使用2毫克17β - 雌二醇和不同剂量的孕酮（50、100或200毫克）。测定了高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）组分以及血清中总胆固醇、游离胆固醇、磷脂、甘油三酯（TG）、载脂蛋白A1和载脂蛋白B的浓度。HDL水平升高，LDL水平降低，而VLDL中的TG水平保持不变，这表明脂蛋白模式是由雌激素诱导的，孕酮几乎没有影响。
