Felding C, Mikkelsen A L, Clausen H V, Loft A, Larsen L G
Department of Obstetrics and Gynaecology, University of Copenhagen, Glostrup County Hospital, Denmark.
Maturitas. 1992 Dec;15(3):241-9. doi: 10.1016/0378-5122(92)90208-l.
To disclose a clinical and histopathological effect of local low-dose oestradiol treatment on the vagina.
A randomised, double-blind trial.
Two gynaecological departments at University Hospitals.
Forty-eight postmenopausal women scheduled for surgery because of genital prolapse.
25 micrograms oestradiol or placebo, administered as vaginal pessaries daily, 3 weeks prior to surgery.
Cytological, histological and clinical changes of the vaginal mucosa.
The thickness of the vaginal wall increased as did the oestrogenic index. No clinical effect was seen apart from decreased incidence of recurrent cystitis postoperatively.
Preoperative oestrogen treatment has been shown to reduce the incidence of recurrent cystitis and may be needed for stimulation of vaginal mucosa; the short-term clinical effect is not convincing, however.
揭示局部低剂量雌二醇治疗对阴道的临床及组织病理学影响。
一项随机双盲试验。
大学医院的两个妇科科室。
48名因生殖器脱垂而计划接受手术的绝经后女性。
术前3周，每天使用阴道栓剂给予25微克雌二醇或安慰剂。
阴道黏膜的细胞学、组织学及临床变化。
阴道壁厚度增加，雌激素指数也增加。除术后复发性膀胱炎发病率降低外，未观察到其他临床效果。
术前雌激素治疗已被证明可降低复发性膀胱炎的发病率，可能需要用于刺激阴道黏膜；然而，短期临床效果并不令人信服。
