Hammerman M R, Ryan G, Miller S B
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Mo. 63110.
Miner Electrolyte Metab. 1992;18(2-5):253-5.
Insulin-like growth factors (IGFs) I and II are proinsulin-like peptides. IGF I is produced in adult and embryonic kidney. It is likely that IGF I produced locally in adult kidney regulates processes of renal transport, metabolism and growth. Renal IGF I production is stimulated by growth hormone (GH) and by epidermal growth factor (EGF). The identity of additional factors that regulate IGF I gene expression in settings such as compensatory hypertrophy and diabetes mellitus is unknown. IGF I and IGF II produced in embryonic kidney promote the metanephrogenic process. The identity of factors that regulate metanephric IGF gene expression is yet to be determined.
胰岛素样生长因子（IGFs）I和II是类胰岛素肽。IGF I在成年和胚胎肾脏中产生。成年肾脏局部产生的IGF I可能调节肾脏的转运、代谢和生长过程。生长激素（GH）和表皮生长因子（EGF）可刺激肾脏产生IGF I。在诸如代偿性肥大和糖尿病等情况下，调节IGF I基因表达的其他因素尚不清楚。胚胎肾脏中产生的IGF I和IGF II促进后肾发生过程。调节后肾IGF基因表达的因素尚未确定。
