Fan Mingwen, Jiang Qianzhou, Bian Zhuan
Department of Endodontics, College of Stomatology, Wuhan University, Wuhan 430070, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2003 Oct;21(5):339-41.
To investigate the effect of specific anti-streptococcus mutans IgY against streptococcus mutans on dental caries development in rats.
35 wistar rats were divided into 5 groups: group A received IgY gargle; group B received IgY lyophilized powder; group C received sterilized water as control; group D and E received egg yolk food with or without specific IgY individually. They were all fed with caries-inducing diet 2000#. The number of caries scores was counted by the procedure of Keyes'.
There was a significant lower mean of caries scores in groups treated with IgY lyophilized powder and gargle. By treating with egg-yolk food contained specific IgY, the mean of caries scores decreased comparing with no treatment group.
Local passive immunization with specific anti-streptococcus mutans IgY may be an effective way to prevent the development of dental caries.
研究特异性抗变形链球菌IgY对大鼠龋齿发展的影响。
将35只Wistar大鼠分为5组：A组接受IgY漱口；B组接受IgY冻干粉；C组接受灭菌水作为对照；D组和E组分别接受含或不含特异性IgY的蛋黄食物。它们均喂食致龋饮食2000#。采用Keyes法计数龋齿得分数量。
接受IgY冻干粉和漱口处理的组中，龋齿得分的平均均值显著更低。通过喂食含特异性IgY的蛋黄食物，与未处理组相比，龋齿得分的均值降低。
用特异性抗变形链球菌IgY进行局部被动免疫可能是预防龋齿发展的有效方法。
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