Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, United States.
School of Life Sciences, University of Technology, Sydney, NSW, Australia.
Front Immunol. 2021 Jun 9;12:696003. doi: 10.3389/fimmu.2021.696003. eCollection 2021.
Antiviral, antibacterial, and antiparasitic drugs and vaccines are essential to maintaining the health of humans and animals. Yet, their production can be slow and expensive, and efficacy lost once pathogens mount resistance. Chicken immunoglobulin Y (IgY) is a highly conserved homolog of human immunoglobulin G (IgG) that has shown benefits and a favorable safety profile, primarily in animal models of human infectious diseases. IgY is fast-acting, easy to produce, and low cost. IgY antibodies can readily be generated in large quantities with minimal environmental harm or infrastructure investment by using egg-laying hens. We summarize a variety of IgY uses, focusing on their potential for the detection, prevention, and treatment of human and animal infections.
抗病毒、抗菌和抗寄生虫药物和疫苗对于维护人类和动物的健康至关重要。然而，它们的生产可能很慢且昂贵，而且一旦病原体产生耐药性，疗效就会丧失。鸡免疫球蛋白 Y（IgY）是人类免疫球蛋白 G（IgG）的高度保守同源物，已在人类传染病的动物模型中显示出益处和良好的安全性。IgY 起效快、易于生产且成本低。通过使用产蛋母鸡，可以最小的环境危害或基础设施投资快速大量地产生 IgY 抗体。我们总结了各种 IgY 的用途，重点介绍了它们在检测、预防和治疗人类和动物感染方面的潜力。
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