利用液相色谱-质谱联用技术（LC-MSn）对溃疡分枝杆菌临床分离株生物合成聚酮类毒素分枝杆菌内酯过程中的共代谢物进行鉴定。
Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans.
作者信息
Hong Hui, Gates Paul J, Staunton James, Stinear Tim, Cole Stewart T, Leadlay Peter F, Spencer Jonathan B
机构信息
Department of Chemistry and Biochemistry, University of Cambridge, Cambridge, UK.
出版信息
Chem Commun (Camb). 2003 Nov 21(22):2822-3. doi: 10.1039/b308163j.
DOI:10.1039/b308163j
PMID:14651122
Abstract
LC-MSn analysis of mycolactone toxin from extracts of Mycobacterium ulcerans has shown that minor co-metabolites, including two previously unreported, differ structurally from mycolactone only in a small portion of the polyketide side-chain.
摘要
对溃疡分枝杆菌提取物中的分枝杆菌内酯毒素进行液相色谱-质谱联用（LC-MSn）分析表明，包括两种此前未报道的在内的次要共代谢产物，其结构与分枝杆菌内酯的差异仅在于聚酮侧链的一小部分。
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