将番茄红素掺入乳糜微粒残粒样颗粒中可增强其对巨噬细胞脂质积累的诱导作用。
Incorporation of lycopene into chylomicron remnant-like particles enhances their induction of lipid accumulation in macrophages.
作者信息
Moore Elizabeth H, Napolitano Mariarosaria, Prosperi Antonella, Avella Michael, Suckling Keith E, Bravo Elena, Botham Kathleen M
机构信息
Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College St., NW1 0TU, London, UK.
出版信息
Biochem Biophys Res Commun. 2003 Dec 26;312(4):1216-9. doi: 10.1016/j.bbrc.2003.11.040.
Lipid accumulation in macrophages exposed to chylomicron remnant-like particles containing the dietary antioxidant lycopene was investigated. After incubation with THP-1 macrophages (48h), chylomicron remnant-like particles containing lycopene (lycCRLPs) as compared to those without (CRLPs) caused significantly more lipid accumulation in the cells, and this was due to increases in both the triacylglycerol (+100%) and cholesterol (+62%) content. In addition, expression of mRNA for diacylglycerol acyltransferase (DGAT), a key enzyme in triacylglycerol synthesis, was significantly decreased by lycCRLPs, but not CRLPs. These findings suggest that lycopene from the diet may promote, rather than retard, lipid accumulation in macrophages during its transport in the blood in chylomicron remnants.
研究了暴露于含有膳食抗氧化剂番茄红素的乳糜微粒残粒样颗粒的巨噬细胞中的脂质积累情况。在用THP-1巨噬细胞孵育48小时后，与不含番茄红素的乳糜微粒残粒样颗粒（CRLPs）相比，含有番茄红素的乳糜微粒残粒样颗粒（lycCRLPs）导致细胞内脂质积累显著增多，这是由于三酰甘油（增加100%）和胆固醇（增加62%）含量均升高所致。此外，三酰甘油合成中的关键酶二酰甘油酰基转移酶（DGAT）的mRNA表达被lycCRLPs显著降低，但CRLPs未使其降低。这些发现表明，饮食中的番茄红素在通过乳糜微粒残粒在血液中运输期间，可能促进而非抑制巨噬细胞中的脂质积累。
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