Culić M, Peković S, Stojiljković M, Saponjić J, Janković B, Rakić L
Institute for Biological Research, Belgrade, Yugoslavia.
Neuroscience. 1992 Nov;51(2):439-44. doi: 10.1016/0306-4522(92)90327-x.
There is a certain recovery of function following brain damage, due to neuronal plasticity. The experiments were performed in order to investigate the effects of cortical lesion on seizural activity in rats induced by systemic application of penicillin. The sensorimotor cortex was unilaterally removed in the lesioned animals, while the control animals were only sham operated or non-operated (before implantation of the electrodes). Seizural activity was recorded by means of electroencephalograms before and after penicillin treatment (1,000,000 I.U./kg, i.p). Testing of penicillin started at least 30 days after cortical lesion. Seizural activity was characterized by spike and wave complexes accompanied by vigilance reduction and sometimes by mild myoclonic jerks in both control and lesioned animals. The early period (about 2 h after penicillin administration) with appearance of the spike-wave discharges with relative increase of the mean total electroencephalogram powers as well as the succeeding period 2.5-5.5 h after penicillin administration) with maximum number of spike-wave discharges did not differ in the electroencephalogram of the control and lesioned animals. The late period of penicillin effect (from 6-11 h after penicillin administration) with frequent spike-wave discharges and still large mean total electroencephalogram powers was observed only in lesioned animals. It is concluded that a cortical lesion destabilizes the brain function in the rat model of epilepsy induced by parenteral administration of penicillin.
由于神经元可塑性，脑损伤后会有一定程度的功能恢复。进行这些实验是为了研究皮层损伤对全身应用青霉素诱导的大鼠癫痫发作活动的影响。在损伤动物中单侧切除感觉运动皮层，而对照动物仅进行假手术或不做手术（在植入电极之前）。在青霉素治疗前后（1,000,000国际单位/千克，腹腔注射）通过脑电图记录癫痫发作活动。青霉素测试在皮层损伤后至少30天开始。在对照动物和损伤动物中，癫痫发作活动的特征是尖波和慢波复合波，伴有警觉性降低，有时伴有轻度肌阵挛性抽搐。青霉素给药后早期（约2小时）出现尖波-慢波放电，平均脑电图总功率相对增加，以及青霉素给药后2.5 - 5.5小时的后续时期（尖波-慢波放电数量最多），对照动物和损伤动物的脑电图没有差异。青霉素作用的后期（青霉素给药后6 - 11小时）出现频繁的尖波-慢波放电且平均脑电图总功率仍然很大，仅在损伤动物中观察到。得出的结论是，在腹腔注射青霉素诱导的癫痫大鼠模型中，皮层损伤会破坏脑功能的稳定性。
