Culic M, Saponjic J, Jankovic B, Rakic L
Institute for Biological Research, Center for Multidisciplinary Studies, Belgrade, Yugoslavia.
Indian J Med Res. 1994 Sep;100:135-9.
Experiments were performed to investigate the effects of cerebellar stimulation on epilepsy induced by parenteral administration of penicillin, in rats without or with the lesion of sensorimotor cortex. There were no differences in the EEG activity of the same experimental animal after the first and subsequent penicillin treatments (at least 7 days later). The electrical stimulation (duration of 5-10 min) of the lateral cerebellar nucleus was applied repetitively 135-315 min after penicillin administration, when the EEG power spectra markedly increased. The cerebellar stimulation evoked the decrease of the mean total EEG power spectra, but the effects were temporary. The EEG power spectra were significantly lower (P < 0.05) during the period of 150-330 min after penicillin treatment in experimental sessions with applied cerebellar stimulation in comparison to the experimental sessions without such stimulation. The residual effects (if any) of cerebellar stimulation on the EEG activity in the later period, 345-600 after penicillin treatment were not significant (P > 0.05). Cerebellar stimulation had the same effect among unlesioned animals and animals with prior cortical lesion in the acute model of epilepsy.
进行了实验，以研究小脑刺激对在无感觉运动皮层损伤或有感觉运动皮层损伤的大鼠中通过肠胃外注射青霉素诱发的癫痫的影响。在首次和随后的青霉素治疗后（至少7天后），同一实验动物的脑电图活动没有差异。在青霉素给药后135 - 315分钟，当脑电图功率谱明显增加时，对小脑外侧核进行重复电刺激（持续5 - 10分钟）。小脑刺激引起平均总脑电图功率谱下降，但效果是暂时的。与未进行这种刺激的实验时段相比，在应用小脑刺激的实验时段中，青霉素治疗后150 - 330分钟期间脑电图功率谱显著更低（P < 0.05）。在青霉素治疗后345 - 600分钟的后期，小脑刺激对脑电图活动的残留影响（如果有的话）不显著（P > 0.05）。在癫痫急性模型中，小脑刺激在未损伤动物和先前有皮层损伤的动物中具有相同的效果。
