Labyt E, Devos D, Bourriez J-L, Cassim F, Destée A, Guieu J-D, Defebvre L, Derambure P
Department of Clinical Neurophysiology, EA2683 MENRT, R. Salengro Hospital, University Medical Center, 59037 Lille Cedex, France.
Clin Neurophysiol. 2003 Dec;114(12):2423-33. doi: 10.1016/s1388-2457(03)00278-5.
This study aimed to investigate changes in spatio-temporal, event-related (de)synchronization (ERD/ERS) patterns recorded with respect to the more akinetic versus the less akinetic side during performance of a visuo-guided targeting movement when compared to an index finger extension.
Twelve de novo parkinsonian patients were recorded. ERD/ERS in mu and beta frequency bands was computed from 21 source derivations.
When the index finger extension was performed with the less akinetic limb, mu ERD focused over contralateral central region appeared 2 s before movement. With the targeting movement, additional pre-movement mu ERD was observed over the parietal region, as well as earlier ipsilateral mu ERD. When the same movements were performed with the more akinetic limb, we observed delayed mu ERD over contralateral regions, earlier ipsilateral mu ERD and a lack of contralateral parietal mu ERD before the targeting movement. Following index finger extension for the less akinetic limb, a focused contralateral central beta ERS was recorded, increasing and spreading after the targeting movement. In contrast, for the more akinetic limb, beta ERS was dramatically attenuated and remained unchanged after the targeting movement.
These results confirm the fact that motor programming is delayed, and provide some insight into what may well be impaired sensorimotor integration in Parkinson's disease.
本研究旨在调查在进行视觉引导的靶向运动时，与食指伸展相比，帕金森病患者运动较少一侧与运动较多一侧相比，时空、事件相关去同步化（ERD）/同步化（ERS）模式的变化。
记录了12例初发帕金森病患者。从21个源记录中计算μ和β频段的ERD/ERS。
当用运动较少的肢体进行食指伸展时，对侧中央区域的μ ERD在运动前2秒出现。在进行靶向运动时，在顶叶区域观察到额外的运动前μ ERD，以及同侧更早出现的μ ERD。当用运动较多的肢体进行相同运动时，我们观察到对侧区域的μ ERD延迟，同侧μ ERD更早出现，并且在靶向运动前缺乏对侧顶叶μ ERD。对于运动较少的肢体，在食指伸展后，记录到对侧中央区域聚焦的β ERS，在靶向运动后增加并扩散。相比之下，对于运动较多的肢体，β ERS显著减弱，并且在靶向运动后保持不变。
这些结果证实了运动编程延迟这一事实，并为帕金森病中可能受损的感觉运动整合提供了一些见解。
