Labyt E, Szurhaj W, Bourriez J-L, Cassim F, Defebvre L, Destée A, Guieu J-D, Derambure Ph
Department of Clinical Neurophysiology, Hospital R. Salengro, Regional University Hospital, CHRU 59037 Cedex, EA 2683, Lille, France.
Clin Neurophysiol. 2003 Jun;114(6):1153-66. doi: 10.1016/s1388-2457(03)00058-0.
In order to better understand the spatio-temporal interaction of the activated cortical areas when the movement is visuo-guided and to assess the age effect on the spatio-temporal pattern of cortical activity, we have compared a proximo-distal movement with visual-motor control and hand-eye coordination (targeting movement) with a distal and a proximal movement.
Brain's electrical activity was studied using the analysis of event-related (de)synchronizations (ERD/S) of cortical mu and beta rhythms in 17 subjects, 8 young and 9 elderly subjects.
In both populations, we found an earlier and broader mu and beta ERD during the preparation of the targeting movement compared to distal and proximal movements, principally involving the contralateral parietal region. During the execution, a spreading over the parietocentral region during proximal movement and over the parietal region during targeting movement was observed. After the execution of proximal and targeting movements, a wider and higher beta ERS was observed only in the young subjects. In the elderly subjects, our results showed a significant decrease of beta ERS during the targeting task.
These results suggest there was a larger recruitment of cortical areas, involving notably the parietal cortex when the movement is visuo-guided. Moreover, cerebral aging-related changes in the spatio-temporal beta ERS pattern suggests an impaired sensory integration.
为了更好地理解视觉引导运动时激活的皮质区域的时空相互作用，并评估年龄对皮质活动时空模式的影响，我们比较了近-远侧运动（视觉-运动控制和手眼协调，即目标导向运动）与远侧和近侧运动。
使用对17名受试者（8名年轻受试者和9名老年受试者）皮质μ和β节律的事件相关（去）同步化（ERD/S）分析来研究大脑的电活动。
在这两个人群中，我们发现与远侧和近侧运动相比，目标导向运动准备期间的μ和β ERD更早且更广泛，主要涉及对侧顶叶区域。在执行过程中，观察到近侧运动期间在顶中央区域扩散，目标导向运动期间在顶叶区域扩散。在执行近侧和目标导向运动后，仅在年轻受试者中观察到更广泛且更高的β ERS。在老年受试者中，我们的结果显示目标导向任务期间β ERS显著降低。
这些结果表明，当运动由视觉引导时，皮质区域的募集更多，尤其涉及顶叶皮质。此外，与大脑衰老相关的时空β ERS模式变化表明感觉整合受损。
