Baykara Nur, Sahin Tülay, Alpar Reha, Solak Mine, Toker Kamil
Department of Anesthesiology, University of Kocaeli Hospital and School of Medicine, University of Kocaeli, Kocaeli, Turkey.
J Clin Anesth. 2003 Sep;15(6):446-50. doi: 10.1016/s0952-8180(03)00110-7.
To establish the relationship between train-of-four (TOF) nerve stimulation and the number of posttetanic twitches (posttetanic count [PTC]) during neuromuscular blockade caused by rocuronium in males and females.
Prospective, observational, clinical comparison.
Operating room of a university hospital.
60 ASA physical status I and II patients (30 women and 30 men), aged 18 to 60 years, who were scheduled for elective orthopedic surgery and ear, nose, throat surgery with a planned duration of 2 hours. INTERVENTIONS; During fentanyl, propofol, and nitrous oxide (N(2)O) anesthesia, neuromuscular blockade was evaluated with accelerometry of the thumb using TOF and posttetanic twitch stimulation (PTTS) of the ulnar nerve in patients who received rocuronium 1 mg.kg(-1).
The first responses to PTTS were seen at mean times of 34.9 and 37.7 minutes after rocuronium injection in male and female patients, respectively (NS). The average interval between the appearance of a posttetanic response and the first response to TOF stimulation (T1) was not significantly different between male and female patients (15.4 +/- 4.8 min (SD) vs. 15.9 +/- 4.9 min, respectively). There was a significant negative correlation between PTC and the time to first response to TOF nerve stimulation (r = -0.83; p = 0.0001). Gender did not have a statistically significant effect on this relation (F = 0.9; p = 0.34). The intervals from administration of rocuronium to the first appearances of T1 and T2 were not significantly different between the two groups, but the intervals to the first appearances of T3 and T4 were significantly longer in female patients.
Even though the times from initial administration of rocuronium 1 mg.kg(-1) to the first appearances of T3 and T4 are significantly longer in female patients, the intervals to the first detectable responses to PTTS and TOF are not significantly different between females and males. Gender has no significant effect on the relation between PTC and the time to T1.
确定男性和女性在罗库溴铵诱导的神经肌肉阻滞期间，四个成串刺激（TOF）与强直后抽搐次数（强直后计数[PTC]）之间的关系。
前瞻性、观察性临床比较。
大学医院手术室。
60例美国麻醉医师协会（ASA）身体状况I级和II级患者（30名女性和30名男性），年龄18至60岁，计划接受择期骨科手术以及耳鼻喉科手术，预计手术时长2小时。干预措施：在芬太尼、丙泊酚和氧化亚氮（N₂O）麻醉期间，对接受1mg·kg⁻¹罗库溴铵的患者，通过拇指加速度计使用TOF以及尺神经强直后抽搐刺激（PTTS）评估神经肌肉阻滞情况。
男性和女性患者在注射罗库溴铵后，首次出现PTTS反应的平均时间分别为34.9分钟和37.7分钟（无显著性差异）。强直后反应出现至首次TOF刺激反应（T1）的平均间隔时间在男性和女性患者之间无显著差异（分别为15.4±4.8分钟[标准差]和15.9±4.9分钟）。PTC与首次TOF神经刺激反应时间之间存在显著负相关（r = -0.83；p = 0.0001）。性别对这种关系无统计学显著影响（F = 0.9；p = 0.34）。两组患者从注射罗库溴铵至首次出现T1和T2的间隔时间无显著差异，但女性患者首次出现T3和T4的间隔时间显著更长。
尽管女性患者从初始给予1mg·kg⁻¹罗库溴铵至首次出现T3和T4的时间显著更长，但女性和男性首次可检测到PTTS和TOF反应的间隔时间无显著差异。性别对PTC与T1时间之间的关系无显著影响。
