Okuzumi J, Nishino H, Murakoshi M, Yamane T, Kitao Y, Inagake M, Ohya K, Yoshida M, Takahashi T
1st Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Oncology. 1992;49(6):492-7. doi: 10.1159/000227099.
The effects of palm carotene on chemical carcinogenesis was studied. Palm carotene suppressed mouse epidermal ornithine decarboxylase activity induced by glycocholic acid. In a two-stage mouse epidermal carcinogenesis experiment using 7,12-dimethylbenz(a)anthracene as the initiator, glycocholic acid as the 1st stage promoter, and mezerein as the 2nd stage promoter, palm carotene inhibited the promoting activity of glycocholic acid. Furthermore, in N-ethyl-N'-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis, 0.05% of palm carotene given in drinking water decreased the percentage of tumor-bearing mice significantly.
研究了棕榈胡萝卜素对化学致癌作用的影响。棕榈胡萝卜素可抑制由甘胆酸诱导的小鼠表皮鸟氨酸脱羧酶活性。在一项以7,12-二甲基苯并(a)蒽为引发剂、甘胆酸为第一阶段促进剂、芫花酯甲为第二阶段促进剂的两阶段小鼠表皮致癌实验中，棕榈胡萝卜素抑制了甘胆酸的促进活性。此外，在N-乙基-N'-硝基-N-亚硝基胍诱导的小鼠十二指肠致癌过程中，饮用水中添加0.05%的棕榈胡萝卜素可显著降低荷瘤小鼠的比例。
