Tan A, Wu K, Huang M
Department of Epidemiology, Tongji Medical University, Wuhan.
Zhonghua Yu Fang Yi Xue Za Zhi. 1995 Nov;29(6):360-2.
Anticarcinogenic action of beta-carotene was analyzed with determination of ornithine decarboxylase (ODC) activity induced by TPA and a two-stage model of skin papilloma-genesis in mice. Results showed increase of ODC activity induced by TPA could be significantly inhibited, onset of tumor postponed, and number of tumor foci decreased by beta-carotene. It suggested beta-carotene had an obvious chemoprophylactic effect on tumor.
通过测定佛波酯（TPA）诱导的鸟氨酸脱羧酶（ODC）活性以及小鼠皮肤乳头状瘤发生的两阶段模型，分析了β-胡萝卜素的抗癌作用。结果显示，β-胡萝卜素可显著抑制TPA诱导的ODC活性增加，延缓肿瘤发生，并减少肿瘤病灶数量。这表明β-胡萝卜素对肿瘤具有明显的化学预防作用。
