Sherman D R, Kloek A P, Krishnan B R, Guinn B, Goldberg D E
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11696-700. doi: 10.1073/pnas.89.24.11696.
Animal globin genes have two introns at strictly conserved positions, while plant globin genes have both of these as well as an additional, central intron. It has been proposed that a common ancestor gene had three introns, one of which was subsequently lost from animal but not plant globin genes. We have elucidated the cDNA sequence and gene structure of a hemoglobin from the parasitic nematode Ascaris suum and found a plant-like central intron, providing strong evidence for a three-intron ancestor of modern globin genes.
动物珠蛋白基因在严格保守的位置有两个内含子，而植物珠蛋白基因不仅有这两个内含子，还有一个额外的中央内含子。有人提出，一个共同的祖先基因有三个内含子，其中一个随后在动物珠蛋白基因中丢失，但在植物珠蛋白基因中没有丢失。我们已经阐明了寄生线虫猪蛔虫血红蛋白的cDNA序列和基因结构，并发现了一个类似植物的中央内含子，为现代珠蛋白基因的三个内含子祖先提供了有力证据。
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