Abdulkarim J A, Dhingsa R, L Finlay D B
Radiology Department, Leicester Royal Infirmary, Leicester, UK.
Clin Radiol. 2003 Dec;58(12):980-4. doi: 10.1016/s0009-9260(03)00255-1.
To ascertain the level at which intervertebral disc degeneration of the cervical spine most commonly occurs in each decade from 20-79 years.
Using computer analysis, we retrospectively assessed the mean signal intensity from each cervical disc from T2-weighted spin-echo images in 60 symptomatic patients (10 per decade from the third to eighth inclusive).
Age, disc level and interaction between age and level were highly significant predictors for the magnetic resonance imaging (MRI) mean signal intensity from intervertebral discs (p<0.0001 for all three terms). The MRI signals were generally lower as age increased and also for the higher discs (C2-C3, etc).
In our study we have shown that in younger patients the higher discs are more frequently affected by degeneration than the lower ones. As age increases, the process of degeneration becomes more generalized with less variability between discs.
确定20至79岁各年龄段颈椎间盘退变最常发生的节段。
通过计算机分析，我们回顾性评估了60例有症状患者（从第三个十年到第八个十年，每十年10例）T2加权自旋回波图像中每个颈椎间盘的平均信号强度。
年龄、椎间盘节段以及年龄与节段之间的相互作用是椎间盘磁共振成像（MRI）平均信号强度的高度显著预测因素（所有三项p<0.0001）。随着年龄增长以及对于较高节段的椎间盘（C2-C3等），MRI信号通常较低。
在我们的研究中，我们表明在较年轻患者中，较高节段的椎间盘比低节段的更易发生退变。随着年龄增加，退变过程变得更加普遍，椎间盘之间的变异性减小。
