McCully James D, Levitsky Sidney
Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School and the Harvard Institutes of Medicine, Boston, MA, USA.
Arch Biochem Biophys. 2003 Dec 15;420(2):237-45. doi: 10.1016/j.abb.2003.06.003.
ATP-sensitive potassium channels allow for the coupling of membrane potential to cellular metabolic status. Two K(ATP) channel subtypes coexist in the myocardium with one subtype located in the sarcolemma membrane and the other in the inner membrane of the mitochondria. The ATP-sensitive potassium channels can be pharmacologically modulated by a family of structurally diverse agents of varied potency and selectivity, collectively known as potassium channel openers and blockers. Sufficient evidence exists to indicate that the ATP-sensitive potassium channels and in particular the mitochondrial ATP-sensitive potassium channels play an important role both as a trigger and an effector in surgical cardioprotection. In this review, the biochemistry and specificity of the ATP-sensitive potassium channels is examined in relation to surgical cardioprotection.
ATP敏感性钾通道可使膜电位与细胞代谢状态相偶联。两种K(ATP)通道亚型共存于心肌中，一种亚型位于肌膜，另一种位于线粒体内膜。ATP敏感性钾通道可被一类结构多样、效力和选择性各异的药物调节，这些药物统称为钾通道开放剂和阻滞剂。有充分证据表明，ATP敏感性钾通道尤其是线粒体ATP敏感性钾通道在心脏手术保护中作为触发因素和效应器均发挥重要作用。在本综述中，将探讨ATP敏感性钾通道的生物化学特性及特异性与心脏手术保护的关系。
