血清脂联素水平与乳腺癌风险的关联。

Association of serum adiponectin levels with breast cancer risk.

作者信息

Miyoshi Yasuo, Funahashi Tohru, Kihara Shinji, Taguchi Tetsuya, Tamaki Yasuhiro, Matsuzawa Yuji, Noguchi Shinzaburo

机构信息

Department of Surgical Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.

出版信息

Clin Cancer Res. 2003 Nov 15;9(15):5699-704.

PMID:14654554

Abstract

PURPOSE

Adiponectin is a peptide hormone secreted from the adipose tissue, affecting the proliferation and insulin sensitivity of various types of cells. Because association of obesity with breast cancer risk is well established, it is possible that adiponectin plays some role in the development of breast cancer. Thus, in the present study, the association of the serum adiponectin levels with breast cancer risk was investigated.

EXPERIMENTAL DESIGN

A case-control study was conducted on 102 breast cancer patients (cases) and 100 healthy women (controls). The serum adiponectin levels of cases and controls were examined in their association with breast cancer risk after adjustment for the various classical risk factors (family history, age at menarche, parity, body mass index, and so forth). In addition, the relationship between the serum adiponectin levels and the various clinicopathological characteristics of breast cancers was studied.

RESULTS

Women in the low tertile of serum adiponectin levels were associated with a significantly (P < 0.005) increased risk for breast cancer compared with women in the high tertile [odds ratio (OR), 3.63; 95% confidence interval (CI), 1.61-8.19]. Such an association was observed both in the premenopausal women (OR, 3.46; 95% CI, 0.89-13.50) and in the postmenopausal women (OR, 3.90; 95% CI, 1.23-12.44). The frequency of large (>2 cm) tumors and that of high histological grade (2+3) tumors were significantly (P < 0.005 and P < 0.05, respectively) higher in breast cancer patients in the low tertile of the serum adiponectin levels than those in the high and intermediate tertiles.

CONCLUSIONS

These results suggest that the low serum adiponectin levels are significantly associated with an increased risk for breast cancer and that tumors arising in women with the low serum adiponectin levels are more likely to show a biologically aggressive phenotype. The association between obesity and breast cancer risk might be partly explained by adiponectin.

摘要

目的

脂联素是一种由脂肪组织分泌的肽类激素，可影响各类细胞的增殖及胰岛素敏感性。鉴于肥胖与乳腺癌风险之间的关联已得到充分证实，脂联素可能在乳腺癌的发生发展中发挥一定作用。因此，在本研究中，我们对血清脂联素水平与乳腺癌风险的关联进行了调查。

实验设计

对102例乳腺癌患者（病例组）和100名健康女性（对照组）进行了一项病例对照研究。在对各种经典风险因素（家族史、初潮年龄、生育情况、体重指数等）进行调整后，研究了病例组和对照组的血清脂联素水平与乳腺癌风险的关联。此外，还研究了血清脂联素水平与乳腺癌各种临床病理特征之间的关系。

结果

血清脂联素水平处于低三分位数的女性与血清脂联素水平处于高三分位数的女性相比，患乳腺癌的风险显著增加（P < 0.005）[比值比（OR），3.63；95%置信区间（CI），1.61 - 8.19]。在绝经前女性（OR，3.46；95% CI，0.89 - 13.50）和绝经后女性（OR，3.90；95% CI，1.23 - 12.44）中均观察到这种关联。血清脂联素水平处于低三分位数的乳腺癌患者中，大肿瘤（>2 cm）和高组织学分级（2 + 3）肿瘤的发生率分别显著高于（分别为P < 0.005和P < 0.05）血清脂联素水平处于高和中三分位数的患者。