作为细胞传感器的瞬时受体电位通道

TRP channels as cellular sensors.

作者信息

Clapham David E

机构信息

Howard Hughes Medical Institute, Pediatric Cardiology, Children's Hospital of Boston, Department of Neurobiology, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA.

出版信息

Nature. 2003 Dec 4;426(6966):517-24. doi: 10.1038/nature02196.

DOI:10.1038/nature02196

PMID:14654832

Abstract

TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.

摘要

瞬时受体电位（TRP）通道是我们感觉系统的先锋，对温度、触觉、疼痛、渗透压、信息素、味觉及其他刺激做出反应。但其作用远不止于经典的感觉转导。它们是细胞（不仅是多细胞生物体）古老的感觉装置，并且已适应于对细胞内外各种刺激做出反应。