Mewissen D J, Rust J H, Haren J, Cluten M J
C R Seances Soc Biol Fil. 1977;171(5):1140-4.
Non-linearity in age specific gompertzian rates regression versus age was observed in actuarial analysis of all causes of death, tumor incidence and tumor/tumor-host index in 503 male and 497 female control C57 Black/6M mice. The overall tumor incidence averaged 66.7% in males and 84.4% in females during a maximum lifespan of 1,300 days. In males as well as in females, time related incidence peaks were identified for lymphocytic lympho-sarcomas, reticulum cell sarcomas, histiocytic type and reticulum cell sarcomas of reticular type.
在对503只雄性和497只雌性对照C57黑/6M小鼠的所有死因、肿瘤发病率和肿瘤/肿瘤宿主指数进行精算分析时,观察到特定年龄的冈珀茨死亡率回归与年龄之间存在非线性关系。在长达1300天的最大寿命期间,雄性小鼠的总体肿瘤发病率平均为66.7%,雌性小鼠为84.4%。在雄性和雌性小鼠中,均确定了淋巴细胞性淋巴瘤、网状细胞肉瘤、组织细胞型和网状型网状细胞肉瘤的时间相关发病率峰值。