Chaves A, Lopes M C, Alves C C, Oliveira C, Peralta L, Rodrigues P, Trindade A
Centro Regional de Oncologia de Coimbra do IPOFG, Departamento de Radioterapia, 3001-651 Coimbra, Portugal.
Med Phys. 2003 Nov;30(11):2904-11. doi: 10.1118/1.1618031.
In radiosurgery narrow photon beams, the depth of maximum dose d(max), in the beam central axis increases as the size of the additional collimator increases. This behavior is the opposite of what is observed in radiotherapy conventional beams. To understand this effect, experimental depth dose curves of the additional collimators were obtained for a Siemens KD2 linear accelerator in 6 MV photon mode and the shift of d(max) varied from 11.0 +/- 0.6 mm for the 5 mm collimator to 14.5 +/- 0.6 mm for the 23 mm collimator. Monte Carlo simulations showed that the photons that had no interactions in the additional collimators, contributing more than 90% to the total dose in water, were responsible for the shift in d(max). Monte Carlo simulations also showed that electrons originated from these photons and contributing to the dose deposit in water in the beam central axis could be divided in two groups: those that deposit energy far away from their point of origin (the point of the first photon collision in water) and those that deposit energy locally (originated at more than one photon collision in water). Applying a simplified model based on the fact that the photons originating Compton electrons (at the first and subsequent collisions) have similar characteristics in air for all the additional collimators, it was shown that these electrons were also responsible for the shift of d(max) in the beam central axis. Finally, it was shown that the changes in the initial gradients of the depth dose curves of the additional collimators were mainly due to electrons originated from the first photon collision in water.
在放射外科的窄光子束中,束中心轴上最大剂量深度d(max)会随着附加准直器尺寸的增加而增大。这种行为与放射治疗传统束中观察到的情况相反。为了理解这种效应,我们获取了西门子KD2直线加速器在6 MV光子模式下附加准直器的实验深度剂量曲线,d(max)的偏移量从5 mm准直器的11.0±0.6 mm变化到23 mm准直器的14.5±0.6 mm。蒙特卡罗模拟表明,在附加准直器中没有相互作用、对水中总剂量贡献超过90%的光子,是导致d(max)偏移的原因。蒙特卡罗模拟还表明,源自这些光子并在束中心轴上对水中剂量沉积有贡献的电子可分为两组:那些在远离其起源点(水中第一个光子碰撞点)沉积能量的电子,以及那些在局部沉积能量的电子(起源于水中不止一次光子碰撞)。基于这样一个事实应用简化模型:对于所有附加准直器,产生康普顿电子(在第一次及后续碰撞中)的光子在空气中具有相似的特性,结果表明这些电子也是束中心轴上d(max)偏移的原因。最后,结果表明附加准直器深度剂量曲线初始梯度的变化主要是由于水中第一次光子碰撞产生的电子。