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使用实验和理论方法调试立体定向放射治疗束。

Commissioning stereotactic radiosurgery beams using both experimental and theoretical methods.

作者信息

Ding George X, Duggan Dennis M, Coffey Charles W

机构信息

Department of Radiation Oncology, B-902, TVC, Vanderbilt University Medical Center, Nashville, TN 37232-5671, USA.

出版信息

Phys Med Biol. 2006 May 21;51(10):2549-66. doi: 10.1088/0031-9155/51/10/013. Epub 2006 May 4.

Abstract

The purpose of this investigation is to study the feasibility of using an alternative method to commission stereotactic radiosurgery beams shaped by micro multi-leaf collimators by using Monte Carlo simulations to obtain beam characteristics of small photon beams, such as incident beam particle fluence and energy distributions, scatter ratios, depth-dose curves and dose profiles where measurements are impossible or difficult. Ionization chambers and diode detectors with different sensitive volumes were used in the measurements in a water phantom and the Monte Carlo codes BEAMnrc/DOSXYZnrc were used in the simulation. The Monte Carlo calculated data were benchmarked against measured data for photon beams with energies of 6 MV and 10 MV produced from a Varian Trilogy accelerator. The measured scatter ratios and cross-beam dose profiles for very small fields are shown to be not only dependent on the size of the sensitive volume of the detector used but also on the type of detectors. It is known that the response of some detectors changes at small field sizes. Excellent agreement was seen between scatter ratios measured with a small ion chamber and those calculated from Monte Carlo simulations. The values of scatter ratios, for field sizes from 6 x 6 mm2 to 98 x 98 mm2, range from 0.67 to 1.0 and from 0.59 to 1.0 for 6 and 10 MV, respectively. The Monte Carlo calculations predicted that the incident beam particle fluence is strongly affected by the X-Y-jaw openings, especially for small fields due to the finite size of the radiation source. Our measurement confirmed this prediction. This study demonstrates that Monte Carlo calculations not only provide accurate dose distributions for small fields where measurements are difficult but also provide additional beam characteristics that cannot be obtained from experimental methods. Detailed beam characteristics such as incident photon fluence distribution, energy spectra, including composition of primary and scattered photons, can be independently used in dose calculation models and to improve the accuracy of measurements with detectors with an energy-dependent response. Furthermore, when there are discrepancies between results measured with different detectors, the Monte Carlo calculated values can indicate the most correct result. The data set presented in this study can be used as a reference in commissioning stereotactic radiosurgery beams shaped by a BrainLAB m3 on a Varian 2100EX or 600C accelerator.

摘要

本研究的目的是通过蒙特卡罗模拟来获取小光子束的射束特性,如入射束粒子注量和能量分布、散射比、深度剂量曲线和剂量剖面(在无法或难以进行测量的情况下),以此研究使用替代方法来委托由微型多叶准直器形成的立体定向放射外科射束的可行性。在水模测量中使用了具有不同灵敏体积的电离室和二极管探测器,并在模拟中使用了蒙特卡罗代码BEAMnrc/DOSXYZnrc。将蒙特卡罗计算数据与瓦里安Trilogy加速器产生的6MV和10MV光子束的测量数据进行基准比对。结果表明,对于非常小的射野,测量得到的散射比和跨射束剂量剖面不仅取决于所用探测器灵敏体积的大小,还取决于探测器的类型。众所周知,某些探测器的响应在小射野尺寸下会发生变化。使用小型电离室测量的散射比与蒙特卡罗模拟计算得到的散射比之间呈现出极好的一致性。对于6MV和10MV的射野,射野尺寸从6×6mm2到98×98mm2时,散射比的值分别在0.67至1.0以及0.59至1.0的范围内。蒙特卡罗计算预测,入射束粒子注量受X-Y光阑开口的强烈影响,特别是对于小射野,这是由于辐射源的有限尺寸所致。我们的测量证实了这一预测。本研究表明,蒙特卡罗计算不仅能为难以测量的小射野提供准确的剂量分布,还能提供无法从实验方法获得的额外射束特性。诸如入射光子注量分布、能谱(包括原光子和散射光子的组成)等详细的射束特性可独立用于剂量计算模型,并提高具有能量依赖响应的探测器的测量精度。此外,当不同探测器测量结果存在差异时,蒙特卡罗计算值可指示出最正确的结果。本研究中给出的数据集可作为在瓦里安2100EX或600C加速器上委托由BrainLAB m3形成的立体定向放射外科射束时的参考。

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