Wenzel S
National Jewish Medical and Research Center, Denver, CO 80206, USA.
Clin Exp Allergy. 2003 Dec;33(12):1622-8. doi: 10.1111/j.1365-2222.2003.01799.x.
The mechanisms behind the development of severe asthma are poorly understood. However, these patients disproportionately consume healthcare resources related to asthma. Severe asthma may develop over time, or may develop shortly after onset of the disease. The genetic and environmental elements that may be most important in the development of severe disease are poorly understood. Physiologically, these patients often have air trapping and airway collapsibility. The pathology demonstrates a heterogeneity of findings, including continued eosinophilic inflammation, an apparently different pathology, structural changes likely to be remodelling related, and predominant distal disease. Treatment remains problematic and likely will remain so until a better understanding of this disease develops.
重度哮喘发展背后的机制尚不清楚。然而，这些患者过度消耗与哮喘相关的医疗资源。重度哮喘可能随时间发展，也可能在疾病发作后不久就出现。对于重度疾病发展中可能最为重要的遗传和环境因素，人们了解甚少。从生理角度来看，这些患者常存在气体潴留和气道可塌陷性。病理表现呈现出异质性，包括持续的嗜酸性粒细胞炎症、明显不同的病理改变、可能与重塑相关的结构变化以及主要的远端疾病。治疗仍然存在问题，而且在对这种疾病有更好的了解之前可能会一直如此。
