Dejlanin-Ilić M, Ilić S
Institute for Prevention, Treatment and Rehabilitation of Rheumatic and Cardiovascular Patients, Niska Banja.
Srp Arh Celok Lek. 1992 Mar-Apr;120(3-4):89-92.
In a group of 60 patients with coronary artery disease and complex ventricular arrhythmias which were recorded by 24-hour ambulatory electrocardiogram, circadian variation of ventricular arrhythmias was analysed. All patients had multiform ventricular premature beats: 40 (67%) patients had pairs of ventricular premature beats; 26 (43%) patients had episodes of ventricular tachycardia, and 8 (13%) patients had R on T type of ventricular premature beats. The most frequent multiform ventricular premature contraction was recorded between 7 and 10 h. a. m. and between 5 and 8 h. p. m. Similar bimodal distribution in frequency of pairs of ventricular premature beats and episodes of ventricular tachycardia, was recorded. Episodes of both symptomatic and asymptomatic types of myocardial ischaemia showed a circadian rhythm similar to that seen in complex ventricular arrhythmias. The study revealed the existence of significant circadian rhythm of ventricular arrhythmias in coronary patients which may be important for chronopharmacologic approach to antiarrhythmic therapy.
在一组60例患有冠状动脉疾病且伴有复杂室性心律失常（通过24小时动态心电图记录）的患者中，分析了室性心律失常的昼夜变化。所有患者均有多形性室性早搏：40例（67%）患者有室性早搏成对出现；26例（43%）患者有室性心动过速发作，8例（13%）患者有R波落在T波上型室性早搏。最频发的多形性室性早搏记录于上午7点至10点以及下午5点至8点之间。室性早搏成对出现的频率以及室性心动过速发作呈现出相似的双峰分布。有症状和无症状类型的心肌缺血发作均显示出与复杂室性心律失常相似的昼夜节律。该研究揭示了冠心病患者中室性心律失常存在显著的昼夜节律，这对于抗心律失常治疗的时辰药理学方法可能具有重要意义。
