De Scalzi M, De Leonardis V, Calzolari F, Barchielli M, Cinelli P, Chiodi L, Fabiano F S, Vergassola R
G Ital Cardiol. 1984 Jul;14(7):465-70.
Sixteen subjects, mean age 59 +/- 18, 11 normal and 5 with coronary artery disease, all having premature ventricular and/or atrial beats in the standard resting electrocardiogram (ECG), were studied to analyse the chronobiologic parameters of these arrhythmias. Single cosinor analysis of the data obtained by 96-hour ECG performed according to the Holter system, demonstrated: A) significant circadian rhythm in heart rate for all the subjects, with acrophases occurring between 12.56 and 17.36; B) significant circadian rhythms of premature ventricular beats for the majority of the subjects, with acrophases distributed along the 24 hours; C) significant circadian rhythms in premature atrial beats for 8 subjects, with acrophases occurring between 04.24 and 18.12; D) a spectrum of significant ultradian rhythms in heart rate with various periodicities, both in normal and in coronary patients; E) significant ultradian rhythms in premature ventricular beats for 8 subjects with periods ranging from 5h 15' to 17h. Population mean cosinor analysis demonstrated: A) significant circadian group rhythm in heart rate for all the 16 subjects and for the group of 11 normal subjects; B) no significant circadian group rhythm for premature ventricular and atrial beats. These findings suggest that the study of the individual chronobiologic pattern of premature beats may help to optimize antiarrhythmic therapy.
16名受试者，平均年龄59±18岁，其中11名正常，5名患有冠状动脉疾病，所有人在标准静息心电图（ECG）中均有室性和/或房性早搏，对这些心律失常的时间生物学参数进行了研究。根据动态心电图系统进行的96小时心电图所获得数据的单余弦分析表明：A）所有受试者的心率均有显著的昼夜节律，峰值相位出现在12.56至17.36之间；B）大多数受试者的室性早搏有显著的昼夜节律，峰值相位分布在24小时内；C）8名受试者的房性早搏有显著的昼夜节律，峰值相位出现在04.24至18.12之间；D）正常人和冠心病患者的心率均有一系列不同周期的显著超日节律；E）8名受试者的室性早搏有显著的超日节律，周期从5小时15分至17小时不等。总体平均余弦分析表明：A）16名受试者以及11名正常受试者组的心率均有显著的昼夜组节律；B）室性和房性早搏无显著的昼夜组节律。这些发现表明，研究早搏的个体时间生物学模式可能有助于优化抗心律失常治疗。
