Jeremić B, Grujicić D, Antunović V, Pantović M, Stojanović M, Jovanović D, Mijatović Lj
Department of Oncology, University Hospital, Kragujevac.
Srp Arh Celok Lek. 1992 May-Jun;120(5-6):161-6.
Between 1980 and 1985 we treated 21 patients with primary spinal cord tumors. There were two diffuse and ten localized ependymoma, six low grade astrocytoma and three malignant glioma. Surgery consisted of total resection in six patients, subtotal resection in three and biopsy in twelve patients. Radiation doses ranged 45-55 Gy. Median age was 55 years (34-70 years), and median follow-up after therapy was 5 years (1-9 years). For patients with localized ependymoma, overall survival and 5-year recurrence-free survival are 80%. Of two patients with diffuse ependymoma, one is alive with no evidence of disease 6 years after the initial diagnosis, while the other is dead. Overall survival and 5 years recurrence-free survival for patients with low grade astrocytoma are 83% and 67%, respectively. All three patients with malignant glioma died of local recurrence (one had diffuse craniospinal metastases, too) one year after the initial diagnosis. Radiotherapy is therapy of choice after surgery in primary spinal cord tumors in adults, although local recurrences remain the major problem.
1980年至1985年间，我们治疗了21例原发性脊髓肿瘤患者。其中有2例弥漫性室管膜瘤、10例局限性室管膜瘤、6例低级别星形细胞瘤和3例恶性胶质瘤。手术方式包括6例全切除、3例次全切除和12例活检。放疗剂量为45 - 55 Gy。中位年龄为55岁（34 - 70岁），治疗后的中位随访时间为5年（1 - 9年）。对于局限性室管膜瘤患者，总生存率和5年无复发生存率均为80%。2例弥漫性室管膜瘤患者中，1例在初次诊断6年后存活且无疾病证据，另1例死亡。低级别星形细胞瘤患者的总生存率和5年无复发生存率分别为83%和67%。3例恶性胶质瘤患者均在初次诊断1年后死于局部复发（1例还伴有弥漫性颅脊髓转移）。放疗是成人原发性脊髓肿瘤手术后的首选治疗方法，尽管局部复发仍然是主要问题。
